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原发性高血压患者载脂蛋白B3'高变区分析

Analysis of the apolipoprotein B3' hypervariable region in patients with essential hypertension.

作者信息

Higashimori K, Higaki J, Miki T, Kamitani A, Mikami H, Kumahara Y, Ogihara T

机构信息

Department of Geriatric Medicine, Osaka University Medical School, Japan.

出版信息

Clin Exp Pharmacol Physiol Suppl. 1992;20:21-3.

PMID:1446404
Abstract
  1. The typing of the apolipoprotein B 3' hypervariable region was investigated in hypertensive and normotensive subjects using rapid typing of a variable number of tandemly repeated short DNA sequences (VNTR) by the polymerase chain reaction. 2. In the DNA samples of 89 normotensive and 99 hypertensive patients, 13 different-sized alleles were detected. The most frequent allele has 35 repeat units in both groups with frequencies of 0.624 and 0.596 in normotensive and hypertensive patients, respectively. Frequency distribution of 13 alleles was similar in both groups. 3. These results demonstrate no association between the apolipoprotein B gene polymorphism and essential hypertension.
摘要
  1. 运用聚合酶链反应对可变数量串联重复短DNA序列（VNTR）进行快速分型，研究了高血压患者和血压正常者载脂蛋白B 3'高变区的分型情况。2. 在89名血压正常者和99名高血压患者的DNA样本中，检测到13个不同大小的等位基因。两组中最常见的等位基因均有35个重复单位，在血压正常者和高血压患者中的频率分别为0.624和0.596。两组中13个等位基因的频率分布相似。3. 这些结果表明，载脂蛋白B基因多态性与原发性高血压之间无关联。

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