McDiarmid M A, Schaefer J, Richard C L, Chaisson R E, Tepper B S
Johns Hopkins Medical Institutions, Baltimore.
Chest. 1992 Dec;102(6):1764-6. doi: 10.1378/chest.102.6.1764.
Aerosolized pentamidine administration may pose potential risks to health care workers exposed to fugitive drug and to infectious respiratory pathogens (eg, tuberculosis) generated by pentamidine-induced cough. Classic infection control methods may be applied to this problem, although the effectiveness of these measures in mitigating environmental pentamidine exposure is unknown. Lack of data fully characterizing pentamidine's mechanism of action or potential mutagenicity, carcinogenicity, or teratogenicity raises concern and suggests worker exposed and environmental contamination be minimized. We report herein on the efficacy of an aerosol containment hood in containing fugitive pentamidine aerosol during administration.
雾化喷他脒给药可能会对接触到逸出药物的医护人员以及由喷他脒诱发咳嗽产生的传染性呼吸道病原体（如结核）构成潜在风险。经典的感染控制方法可应用于这一问题，尽管这些措施在减轻环境中喷他脒暴露方面的有效性尚不清楚。由于缺乏充分描述喷他脒作用机制或潜在的致突变性、致癌性或致畸性的数据，令人担忧，并建议尽量减少工作人员暴露和环境污染。我们在此报告一种气溶胶防护罩在喷他脒给药期间对逸出气溶胶的 containment 效果。 （注：“containment”此处可能是“抑制、控制”等意思，结合语境不太好准确翻译为一个合适的中文词，暂保留英文）
