LIEBERMAN J, KELLOGG F
Calif Med. 1961 Nov;95(5):278-82.
An investigation of the pulmonary fibrinolytic enzyme system in 31 infants who died with hyaline membrane formation was reviewed. There was complete lack of plasminogen activator activity in the lungs of 84 per cent of these infants. This phenomenon was shown to result from an abnormal inhibitor. A comparable inhibitor was found in normal placental tissue, and it is postulated that this inhibitor is released into the circulating blood as the result of placental infarction. Fibrin, a basic component of the hyaline membrane, is probably precipitated from a physiological capillary transudate associated with the formation of amniotic fluid by the lungs. The presence of an inhibitor of fibrinolysis would then result in the accumulation of intrapulmonary fibrin and the formation of hyaline membranes.
对31例死于透明膜形成的婴儿的肺纤维蛋白溶解酶系统进行了回顾性研究。这些婴儿中84%的肺部完全缺乏纤溶酶原激活物活性。已证明这种现象是由一种异常抑制剂导致的。在正常胎盘组织中发现了一种类似的抑制剂，据推测，这种抑制剂是由于胎盘梗死而释放到循环血液中的。透明膜的一种基本成分纤维蛋白，可能是从与肺羊水形成相关的生理性毛细血管渗出液中沉淀出来的。纤溶抑制物的存在会导致肺内纤维蛋白的积累和透明膜的形成。
