Tragl K H, Angelberger P, Pils P, Wiesinger F, Kletter K
Rofo. 1977 Oct;127(4):365-9. doi: 10.1055/s-0029-1230718.
Scintigraphic visualization of the adrenals is greatly improved after substitution of 131I-19-I-Cholesterol by 6beta-131I-Iodomethyl-Cholesterol which was first seen as a radiochemical impurity during the synthesis of 131I-19-Iodocholesterol. The interpretation of the scintigraphic imaging is further improved by application of a cross section through the visualized adrenals. In an animal experiment the radioactivity of the adrenals and to a less degree that of different tissues was found up to four times higher after injection of 6beta-131I-Iodomethyl-Cholesterol than with the applications of 131I-19-Iodocholesterol. The high affinity of the tissue for 6beta-131I-Iodomethyl-Cholesterol results in high radiation exposure of the patients. However, since less activity of 6beta-131I-Iodomethyl-Cholesterol is necessary for visualization of the adrenals the overall radiation is also less than with the application of 131I-Iodocholesterol. Higher stability of the labelled molecule is suggested to be responsible for improved scintigraphic imaging of the adrenals.
在用6β-131I-碘甲基胆固醇替代131I-19-碘胆固醇后，肾上腺的闪烁显像得到了极大改善，6β-131I-碘甲基胆固醇最初是在131I-19-碘胆固醇的合成过程中作为一种放射化学杂质被发现的。通过对可视化肾上腺进行横断面成像，闪烁成像的解读得到了进一步改善。在一项动物实验中，注射6β-131I-碘甲基胆固醇后，肾上腺的放射性以及不同组织的放射性（程度较轻）比注射131I-19-碘胆固醇时高出四倍。组织对6β-131I-碘甲基胆固醇的高亲和力导致患者受到高辐射暴露。然而，由于肾上腺显像所需的6β-131I-碘甲基胆固醇活性较低，总体辐射也比使用131I-碘胆固醇时要少。标记分子更高的稳定性被认为是肾上腺闪烁成像改善的原因。
