Tragl K H, Kletter K
Acta Med Austriaca. 1978;5(4-5):150-2.
The use of 6 beta-131I-Iodomethyl-Cholesterol as an adrenal imaging agent instead of 131I-19-Iodocholesterol has improved the szintigraphic visualization of the adrenals and radiation safety as well. Best results are obtained with respectively unilateral changes of the adrenals or with steroid producing tumors. Pheochromocytomas are diagnosed by decreased uptake of iodinated cholesterol by the adrenals. Possible therapeutic application of radiocholesterol in steroid producing tumors of the adrenals is discussed.
使用6β-131I-碘甲基胆固醇作为肾上腺显像剂而非131I-19-碘胆固醇，改善了肾上腺的闪烁显像可视化效果，同时也提高了辐射安全性。肾上腺单侧改变或类固醇生成肿瘤分别能取得最佳结果。嗜铬细胞瘤可通过肾上腺对碘化胆固醇摄取减少来诊断。文中还讨论了放射性胆固醇在肾上腺类固醇生成肿瘤中的可能治疗应用。
