Meiosis I non-disjunction as the main cause of trisomy 21.
作者信息
Robinson J A
出版信息
Hum Genet. 1977 Nov 2;39(1):27-30. doi: 10.1007/BF00273150.
PMID:144698
Abstract
The relative roles of Meiosis I and Meiosis II non-disjunctions in the causation of trisomy 21 have been assessed by analysing the distribution of polymorphic phenotypes of the chromosomes 21 in a group of individuals with Down's syndrome. The data suggest that the majority of cases of trisomy 21 are due to meiosis I non-disjunctions.
摘要
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