21三体综合征中母亲年龄与不分离的起源
Maternal age and origin of non-disjunction in trisomy 21.
作者信息
Mattei J F, Ayme S, Mattei M G, Giraud F
出版信息
J Med Genet. 1980 Oct;17(5):368-72. doi: 10.1136/jmg.17.5.368.
Abstract
The role of maternal age in chromosomal non-disjunction was investigated by studying 51 families in whom the origin of the meiotic anomaly had been identified. Results of this study were compared with previously published data. This comparison did not show any difference in mean maternal age, nor in distribution of maternal ages when the origin of non-disjunction was maternal, or paternal, or occurred at the first or second meiotic division. These results make questionable the role of maternal age in the birth of Down's syndrome children.
摘要
通过对51个已确定减数分裂异常起源的家庭进行研究，探讨了母亲年龄在染色体不分离中的作用。本研究结果与之前发表的数据进行了比较。当染色体不分离的起源是母亲、父亲或发生在第一次或第二次减数分裂时，这种比较在母亲平均年龄或母亲年龄分布上均未显示出任何差异。这些结果使得母亲年龄在唐氏综合征患儿出生中的作用受到质疑。
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