Totaro R, De Matteis G, Marini C, Prencipe M
Department of Neurology, University of L'Aquila, Italy.
Headache. 1992 Oct;32(9):446-51. doi: 10.1111/j.1526-4610.1992.hed3209446.x.
Transcranial Doppler sonography examination was performed on 44 patients with migraine with aura and 88 controls. All patients were investigated in headache-free periods and 10 of them also during a migraine attack. During the headache-free period a not significant increase of mean flow velocity in patients compared to controls was obtained. The pulsatility index (PI) mean values were also higher in patients than in controls and the differences were significant in the MCA (p < 0.05). No difference between right and left side was observed. During the attack the mean flow velocity (MFV) decreased in all arteries but the decrease was significant only in MCA and ACA (p < 0.05). The mean PI increased in all arteries but not significantly. These variations were observed both on the headache and contralateral side. Nevertheless, the MFV decrease in all arteries was observed in four patients only. In four patients the MFV decrease was found in the anterior arteries and the MFV increase in the posterior arteries, while in two patients the MFV increase was observed both in the anterior and posterior arteries. The correlation between the variations of MFV values during the attacks and the time interval from the onset of attacks showed that the PCA and BA flow velocities were increased in patients examined between 0.5 and 3 hours, while an increase in MCA and ACA flow velocities were observed only in patients examined after 1.5 hours.
对44例伴有先兆的偏头痛患者和88例对照者进行了经颅多普勒超声检查。所有患者均在无头痛期进行检查，其中10例患者在偏头痛发作期间也接受了检查。在无头痛期，与对照组相比，患者的平均血流速度有不显著的增加。患者的搏动指数（PI）平均值也高于对照组，且在大脑中动脉（MCA）差异有统计学意义（p<0.05）。左右两侧未观察到差异。发作期间，所有动脉的平均血流速度（MFV）均下降，但仅在MCA和ACA中下降有统计学意义（p<0.05）。所有动脉的平均PI均升高，但无统计学意义。在头痛侧和对侧均观察到这些变化。然而，仅在4例患者中观察到所有动脉的MFV下降。在4例患者中，前动脉的MFV下降，后动脉的MFV升高，而在2例患者中，前后动脉均观察到MFV升高。发作期间MFV值变化与发作开始后的时间间隔之间的相关性表明，在发作后0.5至3小时接受检查的患者中，大脑后动脉（PCA）和基底动脉（BA）的血流速度增加，而仅在发作后1.5小时接受检查的患者中观察到MCA和ACA血流速度增加。
