MONTANARI R, STOCKHAM M A
Br J Pharmacol Chemother. 1962 Apr;18(2):337-45. doi: 10.1111/j.1476-5381.1962.tb01414.x.
The effects of single and repeated doses of reserpine on the secretion of adrenocorticotrophic hormone (ACTH) were studied in rats by determining changes in the adrenal and plasma concentrations of corticosterone, in the adrenal ascorbic acid levels, and in the adrenal gland weights. Treatment with doses of reserpine which induced sedation caused prolonged hypersecretion of ACTH. Such treatment did not impair the release of ACTH in response to a stressful stimulus as recorded by an increase in the plasma corticosterone even when there was no concomitant depletion in the adrenal ascorbic acid. This finding casts doubt on the value of the adrenal ascorbic acid determination as an index of ACTH secretion.
通过测定大鼠肾上腺皮质酮浓度、血浆皮质酮浓度、肾上腺抗坏血酸水平及肾上腺重量的变化，研究了单剂量和重复剂量利血平对促肾上腺皮质激素（ACTH）分泌的影响。给予能引起镇静作用剂量的利血平进行治疗，会导致ACTH长期分泌过多。即使肾上腺抗坏血酸没有同时耗竭，这种治疗也不会损害应激刺激引起的ACTH释放，血浆皮质酮升高可记录到这种反应。这一发现使人对将肾上腺抗坏血酸测定作为ACTH分泌指标的价值产生怀疑。
