利血平单次及重复给药对促肾上腺皮质激素分泌的影响。
Effects of single and repeated doses of reserpine on the secretion of adrenocorticotrophic hormone.
作者信息
MONTANARI R, STOCKHAM M A
出版信息
Br J Pharmacol Chemother. 1962 Apr;18(2):337-45. doi: 10.1111/j.1476-5381.1962.tb01414.x.
Abstract
The effects of single and repeated doses of reserpine on the secretion of adrenocorticotrophic hormone (ACTH) were studied in rats by determining changes in the adrenal and plasma concentrations of corticosterone, in the adrenal ascorbic acid levels, and in the adrenal gland weights. Treatment with doses of reserpine which induced sedation caused prolonged hypersecretion of ACTH. Such treatment did not impair the release of ACTH in response to a stressful stimulus as recorded by an increase in the plasma corticosterone even when there was no concomitant depletion in the adrenal ascorbic acid. This finding casts doubt on the value of the adrenal ascorbic acid determination as an index of ACTH secretion.
摘要
通过测定大鼠肾上腺皮质酮浓度、血浆皮质酮浓度、肾上腺抗坏血酸水平及肾上腺重量的变化，研究了单剂量和重复剂量利血平对促肾上腺皮质激素（ACTH）分泌的影响。给予能引起镇静作用剂量的利血平进行治疗，会导致ACTH长期分泌过多。即使肾上腺抗坏血酸没有同时耗竭，这种治疗也不会损害应激刺激引起的ACTH释放，血浆皮质酮升高可记录到这种反应。这一发现使人对将肾上腺抗坏血酸测定作为ACTH分泌指标的价值产生怀疑。
相似文献
1
Effects of single and repeated doses of reserpine on the secretion of adrenocorticotrophic hormone.利血平单次及重复给药对促肾上腺皮质激素分泌的影响。
Br J Pharmacol Chemother. 1962 Apr;18(2):337-45. doi: 10.1111/j.1476-5381.1962.tb01414.x.
2
The effect of reserpine on hypothalamo-pituitary-adrenocortical function in the rat.利血平对大鼠下丘脑-垂体-肾上腺皮质功能的影响。
Br J Pharmacol. 1975 Apr;53(4):555-61. doi: 10.1111/j.1476-5381.1975.tb07394.x.
3
Physiological role of corticotropin-releasing factor in the control of adrenocorticotropin-mediated corticosterone release from the rat adrenal gland.促肾上腺皮质激素释放因子在调控大鼠肾上腺中促肾上腺皮质激素介导的皮质酮释放中的生理作用。
Endocrinology. 1992 Jan;130(1):282-8. doi: 10.1210/endo.130.1.1309333.
4
Depletion of pituitary corticotrophin by reserpine and by a nitrogen mustard.利血平和氮芥对垂体促肾上腺皮质激素的耗竭作用。
Br J Pharmacol Chemother. 1960 Mar;15(1):165-9. doi: 10.1111/j.1476-5381.1960.tb01226.x.
5
Stimulation of adrenocorticotropin secretion by insulin-induced hypoglycemia in the developing rat involves arginine vasopressin but not corticotropin-releasing factor.胰岛素诱导的低血糖对发育中大鼠促肾上腺皮质激素分泌的刺激作用涉及精氨酸加压素，而非促肾上腺皮质激素释放因子。
Endocrinology. 1992 May;130(5):2725-32. doi: 10.1210/endo.130.5.1315256.
6
Characteristics of the adrenal ascorbic acid response to adrenocorticotrophic hormone (ACTH) in the rat.大鼠肾上腺抗坏血酸对促肾上腺皮质激素（ACTH）反应的特征
Endocrinology. 1960 Feb;66:149-59. doi: 10.1210/endo-66-2-149.
7
Proceedings: Pituitary-adrenocortical function in the reserpine-treated rat.论文：利血平处理大鼠的垂体 - 肾上腺皮质功能
J Endocrinol. 1974 Apr;61(1):XXVI.
8
Effects of intracerebroventricular injection of histamine and related compounds on corticosterone release in rats.脑室内注射组胺及相关化合物对大鼠皮质酮释放的影响。
Br J Pharmacol. 1993 Jul;109(3):807-13. doi: 10.1111/j.1476-5381.1993.tb13646.x.
9
Dissociation of reserpine-induced sedation and ACTH hypersecretion.利血平诱导的镇静作用与促肾上腺皮质激素分泌过多的解离。
Life Sci (1962). 1962 Apr;1:151-5. doi: 10.1016/0024-3205(62)90044-9.
10
The influence of reserpine on the inhibition of ACTH-secretion induced by exogenous ACTH or a corticoid injection.利血平对外源性促肾上腺皮质激素（ACTH）或皮质类固醇注射诱导的ACTH分泌抑制的影响。
Arzneimittelforschung. 1966 Nov;16(11):1574-6.
引用本文的文献
1
On the site of action of reserpine on ACTH secretion.关于利血平对促肾上腺皮质激素分泌的作用部位。
J Neural Transm. 1972;33(4):289-300. doi: 10.1007/BF01245840.
2
Estrus behaviour in spayed rats after estrogen or progesterone treatment in combination with reserpine or tetrabenazine.切除卵巢的大鼠在雌激素或孕激素与利血平或丁苯那嗪联合治疗后的发情行为。
Psychopharmacologia. 1964 Sep 11;6(3):210-8. doi: 10.1007/BF00404011.
3
The effect of reserpine on hypothalamo-pituitary-adrenocortical function in the rat.利血平对大鼠下丘脑-垂体-肾上腺皮质功能的影响。
Br J Pharmacol. 1975 Apr;53(4):555-61. doi: 10.1111/j.1476-5381.1975.tb07394.x.
本文引用的文献
1
On the assay of corticotrophin: comparison of the plasma corticosteroid and adrenal ascorbic acid response.促肾上腺皮质激素测定：血浆皮质类固醇与肾上腺抗坏血酸反应的比较
Acta Endocrinol (Copenh). 1961 Oct;38:220-35. doi: 10.1530/acta.0.0380220.
2
Effects of reserpine and cold-exposure on pituitary-adrenocortical function in rats.利血平和冷暴露对大鼠垂体-肾上腺皮质功能的影响。
J Pharmacol Exp Ther. 1961 Nov;134:167-75.
3
Depletion of pituitary corticotrophin by reserpine and by a nitrogen mustard.利血平和氮芥对垂体促肾上腺皮质激素的耗竭作用。
Br J Pharmacol Chemother. 1960 Mar;15(1):165-9. doi: 10.1111/j.1476-5381.1960.tb01226.x.
4
"Inhibition" of pituitary ACTH release after administration of reserpine or epinephrine.给予利血平或肾上腺素后垂体促肾上腺皮质激素释放的“抑制”
Endocrinology. 1959 Oct;65:548-54. doi: 10.1210/endo-65-4-548.
5
Diurnal rhythm in plasma corticosterone and lack of diurnal rhythm in plasma compound F-like material in the rat.大鼠血浆皮质酮的昼夜节律及血浆中类化合物F物质缺乏昼夜节律。
Proc Soc Exp Biol Med. 1960 Aug-Sep;104:787-9. doi: 10.3181/00379727-104-25988.
6
Activity of pituitary-adrenal cortex axis during acute and chronic reserpine treatment.利血平急性和慢性治疗期间垂体 - 肾上腺皮质轴的活性
Proc Soc Exp Biol Med. 1961 Mar;106:579-81. doi: 10.3181/00379727-106-26408.
7
Studies on the time course of the response of the adrenal cortex to histamine and cold.肾上腺皮质对组胺和寒冷反应的时间进程研究。
Can J Biochem Physiol. 1959 Mar;37(3):399-404.
8
The estimation of small amounts of corticosterone in rat plasma.大鼠血浆中少量皮质酮的测定。
J Biol Chem. 1958 Apr;231(2):695-701.
9
Fate of adrenal ascorbic acid: relationship to corticosteroid secretion.肾上腺抗坏血酸的命运：与皮质类固醇分泌的关系。
Endocrinology. 1957 Jul;61(1):98-105. doi: 10.1210/endo-61-1-98.
10
Role of brain serotonin in reserpine action.脑血清素在利血平作用中的角色。
Ann N Y Acad Sci. 1957 Mar 14;66(3):609-15; discussion, 615-7. doi: 10.1111/j.1749-6632.1957.tb40751.x.
Zotero 插件