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Synthesis and serotonergic pharmacology of the enantiomers of 3-[(N-methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin.

作者信息

Macor J E, Blake J, Fox C B, Johnson C, Koe B K, Lebel L A, Morrone J M, Ryan K, Schmidt A W, Schulz D W

机构信息

Department of Medicinal Chemistry, Pfizer, Inc, Groton, Connecticut 06340.

出版信息

J Med Chem. 1992 Nov 13;35(23):4503-5. doi: 10.1021/jm00101a032.

DOI:10.1021/jm00101a032
PMID:1447752
Abstract
摘要

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Synthesis and serotonergic pharmacology of the enantiomers of 3-[(N-methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin.3-[(N-甲基吡咯烷-2-基)甲基]-5-甲氧基-1H-吲哚对映体的合成及血清素能药理学：在神经递质血清素的氨乙基侧链中发现立体异构分化
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