NAGANNA B, RAO B R, VENKAIAH K R, RAO P L
J Clin Pathol. 1962 Jan;15(1):73-5. doi: 10.1136/jcp.15.1.73.
The serum of a case of hyperglobulinaemia with negative thymol and zinc sulphate turbidity reactions was studied. The serum when added to pathological sera with high turbidity values brought about a marked reduction in the original turbidity values. Also, the serum did not give the usual copper proteinate precipitate when added to copper sulphate solutions. The anomalous protein fraction responsible for the above properties was isolated from the gamma globulins by precipitation at 28% saturation with ammonium sulphate. It was found to be neither a macroglobulin (Waldenstrom's), a cryoglobulin, nor a collagen protein. Its occurrence in the very gamma globulin fraction which is responsible for many of the turbidity reactions is of great significance in the interpretation of these tests. It is suggested that the normal turbidity and flocculation reactions reported in some cases of multiple myelomatosis might be due to some such anomalous proteins.
对一例麝香草酚和硫酸锌浊度反应呈阴性的高球蛋白血症患者的血清进行了研究。将该血清加入到具有高浊度值的病理血清中时，会使原来的浊度值显著降低。此外，当将该血清加入到硫酸铜溶液中时，不会产生通常的铜蛋白沉淀。通过用28%饱和度的硫酸铵沉淀，从γ球蛋白中分离出了具有上述特性的异常蛋白质组分。发现它既不是巨球蛋白（瓦尔登斯特伦氏巨球蛋白）、冷球蛋白，也不是胶原蛋白。它存在于对许多浊度反应起作用的γ球蛋白组分中，这对于解释这些试验具有重要意义。有人提出，某些多发性骨髓瘤病例中报告的正常浊度和絮凝反应可能是由于某些此类异常蛋白质所致。
