NASMYTH P A
Br J Pharmacol Chemother. 1962 Feb;18(1):65-75. doi: 10.1111/j.1476-5381.1962.tb01151.x.
Choline 2,6-xylyl ether potentiated the sympathomimetic effects of tyramine and adrenaline in anaesthetized and spinal cats; the effects of noradrenaline were not significantly affected. The pressor activity of tyramine was also potentiated by the drug in reserpine-treated spinal cats and in pithed rats. The acute intravenous injection of reserpine in pithed rats potentiated pressor responses to tyramine, but depressed those to adrenaline and noradrenaline. During the intravenous infusion of noradrenaline in spinal cats and pithed rats the pressor responses to tyramine were increased, whilst those to adrenaline and noradrenaline were decreased. Infusion of isoprenaline in a spinal cat depressed responses to tyramine and noradrenaline, but potentiated those to adrenaline. A lower rate of infusion of isoprenaline in the same animal subsequently potentiated adrenaline and noradrenaline, but continued to depress tyramine. These results are held to be inconsistent with the view that the sympathomimetic effects of tyramine are produced entirely by the release of catechol amines.
胆碱2,6 - 二甲苯基醚增强了酪胺和肾上腺素对麻醉猫和脊髓猫的拟交感神经作用；去甲肾上腺素的作用未受到显著影响。在利血平处理的脊髓猫和去脑大鼠中，该药物也增强了酪胺的升压活性。给去脑大鼠急性静脉注射利血平可增强对酪胺的升压反应，但减弱对肾上腺素和去甲肾上腺素的反应。在脊髓猫和去脑大鼠静脉输注去甲肾上腺素期间，对酪胺的升压反应增强，而对肾上腺素和去甲肾上腺素的反应减弱。在脊髓猫中输注异丙肾上腺素会减弱对酪胺和去甲肾上腺素的反应，但增强对肾上腺素的反应。在同一动物中以较低速率输注异丙肾上腺素随后会增强肾上腺素和去甲肾上腺素，但继续减弱对酪胺的反应。这些结果被认为与酪胺的拟交感神经作用完全由儿茶酚胺释放产生的观点不一致。
