BEJRABLAYA D, BURN J H, WALKER J M
Br J Pharmacol Chemother. 1958 Dec;13(4):461-6. doi: 10.1111/j.1476-5381.1958.tb00238.x.
When the heart-lung preparation is made from a dog treated with reserpine, catechol amines such as noradrenaline and isoprenaline have a greater effect on the rate of the heart than they have in a preparation from a normal dog. Other sympathomimetic amines such as tyramine and ephedrine, on the other hand, are found to have lost their action. Since treatment with reserpine has been shown to cause the store of noradrenaline in the heart to disappear, and the infusion of noradrenaline into the preparation made from a reserpine-treated animal restores the action of tyramine, it is concluded that substances like tyramine and ephedrine normally act by liberating noradrenaline from the store, and do not act directly. Cocaine, like reserpine, increases the effect of noradrenaline and decreases the effect of tyramine on the heart rate; it appears to block the release of noradrenaline from the store in the heart.
当从用利血平处理过的狗制备心肺标本时，去甲肾上腺素和异丙肾上腺素等儿茶酚胺对心脏速率的影响比在从正常狗制备的标本中更大。另一方面，发现其他拟交感胺如酪胺和麻黄碱已失去其作用。由于已证明用利血平处理会导致心脏中去甲肾上腺素储存消失，并且将去甲肾上腺素注入从用利血平处理过的动物制备的标本中可恢复酪胺的作用，因此得出结论，酪胺和麻黄碱等物质通常通过从储存中释放去甲肾上腺素起作用，而不是直接起作用。可卡因与利血平一样，增加去甲肾上腺素对心率的影响并降低酪胺对心率的影响；它似乎阻断了心脏储存中去甲肾上腺素的释放。
