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小鼠淋巴细胞性脉络丛脑膜炎:从野生小鼠到实验小鼠的自然交叉感染史。

Murine lymphocytic choriomeningitis: the history of a natural cross-infection from wild to laboratory mice.

作者信息

Skinner H H, Knight E H, Grove R

出版信息

Lab Anim. 1977 Oct;11(4):219-22. doi: 10.1258/002367777780936422.

DOI:10.1258/002367777780936422
PMID:144827
Abstract

A new locus of wild house mice tolerantly infected with the virus of lymphocytic choriomeningitis (LCM) has been identified in the United Kingdom. Evidence is presented which indicates that these mice were the source of infection in a laboratory mouse breeding colony, the mode of transmission probably being bites on tails and limbs exposed through wire-grid flooring. The results of an experiment which simulated indirect exposure of SPF mice to tolerantly infected wild mice supported earlier observations that without injury to the epidermis the risk of spread of infection from the infective urine, saliva or faeces is low.

摘要

在英国发现了一个新的野生家鼠位点,这些家鼠能耐受淋巴细胞性脉络丛脑膜炎病毒(LCM)感染。现有证据表明,这些家鼠是一个实验室小鼠繁殖群体的感染源,传播方式可能是通过金属丝网地板暴露在外的尾巴和四肢被咬伤。一项模拟无特定病原体(SPF)小鼠间接接触耐受感染的野生小鼠的实验结果,支持了早期的观察结果,即表皮无损伤时,感染性尿液、唾液或粪便传播感染的风险较低。

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Murine lymphocytic choriomeningitis: the history of a natural cross-infection from wild to laboratory mice.小鼠淋巴细胞性脉络丛脑膜炎:从野生小鼠到实验小鼠的自然交叉感染史。
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