Stenfors L E, Räisänen S
Kliniska laboratoriet, Mellersta-Osterbottens Centralsjukhus, Karleby.
Nord Med. 1992;107(11):278-9.
Otitis media develops when certain bacterial pathogens gain access to the middle ear cavity from the nasopharynx through the eustachian tube. Adhesion of bacteria, in particular Streptococcus pneumoniae and Haemophilus influenzae, to the non-ciliated epithelial cells of the nasopharynx, close to the opening of the eustachian tube, is significantly correlated to the otitis-prone condition in children. Otitis-prone children have significantly fewer bacteria in the nasopharynx coated with the immunoglobulin secretory IgA (SigA) then healthy children have. Adhesion and occurrence of middle ear pathogens in the nasopharynx decreases with advancing age. Epstein-Barr virus, causative agent of infectious mononucleosis, causes a remarkable increase in bacterial adhesion to epithelial cells.
当中耳炎时，某些细菌病原体通过咽鼓管从鼻咽部进入中耳腔。细菌，特别是肺炎链球菌和流感嗜血杆菌，粘附于咽鼓管开口附近的鼻咽部非纤毛上皮细胞，这与儿童易患中耳炎的情况显著相关。易患中耳炎的儿童鼻咽部被免疫球蛋白分泌型IgA（SigA）包被的细菌明显少于健康儿童。随着年龄的增长，鼻咽部中耳病原体的粘附和发生率会降低。传染性单核细胞增多症的病原体爱泼斯坦-巴尔病毒会导致细菌对上皮细胞的粘附显著增加。
