Spireas S S, Jarowski C I, Rohera B D
College of Pharmacy & Allied Health Professions, St. John's University, Jamaica, New York 11439.
Pharm Res. 1992 Oct;9(10):1351-8. doi: 10.1023/a:1015877905988.
The concept of powdered solutions can be used to formulate liquid medications in dry, nonadherent, free-flowing, and readily compressible powders. The technique is based on simple admixture of drug solution or liquid drug with selected carrier and coating materials. Improved drug release profiles are exhibited by such delivery systems even for poorly water-soluble drugs. Previous work using this method has rendered its industrial application impractical because of the unsatisfactory flow properties of the powder admixtures. This article presents a theoretical model based on the principles and mechanism of powdered solutions and introduces a new physical property of powders termed the flowable liquid-retention potential (phi value). Mathematical expressions are derived that can be used to calculate the optimum amount of excipients required to yield powder admixtures with acceptable flowability. The validity and applicability of these expressions have been verified experimentally using clofibrate and prednisolone as test materials. The proposed model is shown to be superior to previously reported studies in optimizing the amount of excipients needed to prepare powdered solutions with acceptable flow properties.
粉末溶液的概念可用于将液体药物制成干燥、不粘连、易流动且易于压缩的粉末。该技术基于药物溶液或液体药物与选定的载体和包衣材料的简单混合。即使对于水溶性差的药物，此类给药系统也能呈现出改善的药物释放曲线。此前使用该方法的工作由于粉末混合物的流动性不理想而使其工业应用不切实际。本文提出了一个基于粉末溶液原理和机制的理论模型，并引入了一种粉末的新物理性质，称为可流动液体保留潜力（φ值）。推导了数学表达式，可用于计算产生具有可接受流动性的粉末混合物所需的最佳辅料量。使用氯贝丁酯和泼尼松龙作为测试材料，通过实验验证了这些表达式的有效性和适用性。结果表明，所提出的模型在优化制备具有可接受流动性质的粉末溶液所需的辅料量方面优于先前报道的研究。
