Division of Pharmaceutical Technology, Faculty of Pharmacy, P.O. Box 56, FI-00014 University of Helsinki, Finland.
Int J Pharm. 2010 Mar 15;387(1-2):65-70. doi: 10.1016/j.ijpharm.2009.12.005. Epub 2009 Dec 25.
In the present study, thin-coating as a potential method for improving flow properties of cohesive ibuprofen powder was introduced. Briefly, the technique was based on the successive deposition of ultrasound-assisted fine polymer mist onto the surface of the powdered active pharmaceutical ingredient (API), producing individual particles with a hydrophilic thin-coat. A 0.15% m/V aqueous solution of hydroxypropyl methylcellulose (HPMC) was used. Particle size and surface analysis revealed a decrease in the cohesiveness of ibuprofen powder and an increase in the homogeneity of particle surfaces as a result of polymer treatment. Superficial changes caused a substantial improvement on the flowing characteristics of coated substance over uncoated. The enhancement in flow rate proceeded as the uniformity of the HPMC layer increased. In conclusion, the proposed technique is a simple and effective method that can be used as a continuous process to modify API particle surface properties, which in turn improve the handling of poorly flowable powder.
在本研究中，引入了薄膜包衣作为改善粘性布洛芬粉末流动性能的一种潜在方法。简而言之，该技术基于超声辅助细聚合物雾滴连续沉积在粉末状活性药物成分（API）的表面，形成具有亲水性薄膜的单个颗粒。使用了 0.15% m/V 的羟丙基甲基纤维素（HPMC）水溶液。颗粒大小和表面分析表明，聚合物处理导致布洛芬粉末的粘性降低，颗粒表面的均一性增加。表面的变化导致涂覆物质的流动特性相对于未涂覆物质有了实质性的改善。随着 HPMC 层均匀性的增加，流速的提高也随之增加。总之，所提出的技术是一种简单有效的方法，可以作为连续工艺来改变 API 颗粒表面性质，从而改善流动性差的粉末的处理。
