Lövblad K O, Steck A J
Service de neurologie, CHUV Lausanne.
Schweiz Rundsch Med Prax. 1992 Nov 24;81(48):1455-7.
Paraneoplastic neurological syndromes are well established causes of neurological dysfunction in cancer patients. Recently an auto-immune origin has been found for the Lambert-Eaton myasthenic syndrome, the subacute sensory neuronopathy of Denny-Brown, the paraneoplastic cerebellar degeneration, the paraneoplastic opsoclonus-myoclonus as well as a few other minor syndromes. Indeed patients suffering from these diseases have been found to produce antibodies directed against the central nervous system. These antibodies can be detected as much as a year before the cancer is found and they are therefore interesting for neurological and oncologic diagnosis.
副肿瘤性神经系统综合征是癌症患者神经功能障碍的公认病因。最近发现,兰伯特-伊顿肌无力综合征、丹尼-布朗亚急性感觉神经元病、副肿瘤性小脑变性、副肿瘤性眼阵挛-肌阵挛以及其他一些少见综合征都有自身免疫起源。事实上,已发现患有这些疾病的患者会产生针对中枢神经系统的抗体。这些抗体在癌症被发现前一年就可被检测到,因此对神经科和肿瘤科诊断具有重要意义。