Grisold W, Drlicek M, Liszka-Setinek U, Wondrusch E
Neurological Department, Kaiser Franz Josef Hospital, Vienna, Austria.
Clin Neurol Neurosurg. 1995 Feb;97(1):106-11. doi: 10.1016/0303-8467(95)00003-3.
Paraneoplastic neurological syndromes have attracted attention in recent years. Detection of auto-antibodies directed against CNS and PNS structures have suggested an autoimmune etiology. This review is based on reports from the past 10 years and summarizes the therapeutic results in 258 patients suffering from paraneoplastic neurological disease including paraneoplastic encephalomyelitis, sensory neuronopathy, cerebellar degeneration, motor neurone disease and stiff man syndrome. The results show that in some entities such as Lambert-Eaton syndrome successful treatment can be expected. In other syndromes such as subacute sensory neuronopathy or paraneoplastic cerebellar degeneration therapeutic success varies from 5 to 10%.
副肿瘤性神经系统综合征近年来已引起关注。针对中枢神经系统和周围神经系统结构的自身抗体检测提示了自身免疫性病因。本综述基于过去10年的报告，总结了258例副肿瘤性神经疾病患者的治疗结果，这些疾病包括副肿瘤性脑脊髓炎、感觉神经元病、小脑变性、运动神经元病和僵人综合征。结果表明，在某些疾病如兰伯特-伊顿综合征中，可以预期获得成功治疗。而在其他综合征如亚急性感觉神经元病或副肿瘤性小脑变性中，治疗成功率在5%至10%之间。
