Jørgensen H S, Plesner A M, Hübbe P, Larsen K
Department of Neurology, Frederiksberg Hospital, Denmark.
Stroke. 1992 Dec;23(12):1701-4. doi: 10.1161/01.str.23.12.1701.
Stroke incidence declined until the end of the 1970s in the United States, and the decline continued into the 1980s in Japan. The purpose of this study was to determine possible temporal changes of stroke incidence in a European community.
A prospective stroke registry was established in the community of Frederiksberg (population, approximately 90,000), Denmark, in the two periods 1972-1974 and 1989-1990. All patients suspected of stroke were clinically evaluated by a neurologist. Only patients with first-ever stroke were included. Complete case ascertainment was ensured by registration of both hospitalized and nonhospitalized patients. Death certificates were also scrutinized.
A total of 927 patients with first-ever stroke was recorded. The annual stroke incidence rate per 1,000 increased by 18% from 2.6 in 1972-1974 to 3.1 in 1989-1990 (p < 0.01). This increase was due solely to a 42% increase in men, in whom stroke incidence rose from 2.1 to 3.0 (p < 0.0005). Incidence was unchanged in women at 3.0 and 3.1, respectively. The incidence rates from 1972-1974 were age and sex adjusted to the 1990 population. After adjustment to the Danish population, stroke incidence in Denmark was 2.0 for all, 2.3 for men, and 1.9 for women. In the second study period computed tomography or necropsy was performed in 85% of cases; 2.4/1,000 had cerebral infarction; 0.20/1,000 had intracerebral hemorrhage; and 0.02/1,000 had subarachnoid hemorrhage.
In a period when decline in stroke incidence has stopped in the United States and has continued in Japan, a marked increase of stroke incidence in Danish men was observed.
在美国，中风发病率在20世纪70年代末之前呈下降趋势，在日本，这一下降趋势持续到了20世纪80年代。本研究的目的是确定欧洲某社区中风发病率可能存在的时间变化。
在丹麦腓特烈斯贝格社区（人口约90,000）于1972 - 1974年和1989 - 1990年这两个时间段建立了前瞻性中风登记处。所有疑似中风的患者均由神经科医生进行临床评估。仅纳入首次发生中风的患者。通过对住院和非住院患者进行登记确保病例完整确诊。还对死亡证明进行了审查。
共记录了927例首次发生中风的患者。每1000人的年中风发病率从1972 - 1974年的2.6上升了18%，至1989 - 1990年为3.1（p < 0.01）。这一上升完全归因于男性发病率上升了42%，男性中风发病率从2.1升至3.0（p < 0.0005）。女性发病率分别为3.0和3.1，无变化。1972 - 1974年的发病率按年龄和性别调整至1990年的人口情况。调整至丹麦人口后，丹麦的中风发病率总体为2.0，男性为2.3，女性为1.9。在第二个研究时间段，85%的病例进行了计算机断层扫描或尸检；每1000人中有2.4例发生脑梗死；每1000人中有0.20例发生脑出血；每1000人中有0.02例发生蛛网膜下腔出血。
在美国中风发病率下降停止而在日本仍持续下降的时期，丹麦男性的中风发病率显著上升。
