Kiiza D A, Artiukh V P, Starodub N F, Khmel'nitskiĭ G A
Ukr Biokhim Zh (1978). 1992 Jul-Aug;64(4):67-72.
It is found that nitrite-ions formed as a result of biotransformation during long term feeding of calves with sodium and potassium nitrates induce changes in some biochemical parameters of blood, including HS-glutathione content in erythrocytes, acid hemolytic resistance of erythrocytes, activity of NAD-dependent methemoglobin-reductase, correlation of ligand forms of hemoglobin and its total content. It is supposed that the observed changes are of an adaptational character and, as a whole, provide for the optimization of both quantitative and qualitative composition of population of erythroid cells at the expense of erythropoiesis intensification.
研究发现，长期用硝酸钠和硝酸钾喂养犊牛时，生物转化过程中形成的亚硝酸根离子会引起血液某些生化参数的变化，包括红细胞中HS-谷胱甘肽含量、红细胞的酸溶血抗性、NAD依赖性高铁血红蛋白还原酶的活性、血红蛋白配体形式及其总含量的相关性。据推测，观察到的这些变化具有适应性特征，总体而言，以增强红细胞生成过程为代价，实现了红系细胞群体数量和质量组成的优化。
