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Possible mechanisms of nitrate tolerance.

作者信息

Elkayam U, Mehra A, Shotan A, Osprzega E

机构信息

Department of Medicine, University of Southern California (USC) Los Angeles 90033.

出版信息

Am J Cardiol. 1992 Nov 27;70(17):49G-53G; discussion 53G-54G. doi: 10.1016/0002-9149(92)90026-u.

DOI:10.1016/0002-9149(92)90026-u
PMID:1449100
Abstract

Prolonged exposure to organic nitrates has been shown to lead to the rapid development of tolerance to the peripheral and coronary vasodilatory effects of these drugs. As a result of this phenomenon, the hemodynamic and anti-ischemic effects of nitrates may be rapidly attenuated in patients with ischemic heart disease, congestive heart failure, or both. This nitrate tolerance appears to be both dose- and time-dependent. Likely mechanisms proposed for its development are multifactorial and include depletion of sulfhydryl groups, a nitrate-mediated increase in blood volume, and neurohormonal stimulation with activation of vasoconstrictive mechanisms.

摘要

相似文献

1
Possible mechanisms of nitrate tolerance.
Am J Cardiol. 1992 Nov 27;70(17):49G-53G; discussion 53G-54G. doi: 10.1016/0002-9149(92)90026-u.
2
Tolerance to organic nitrates: evidence, mechanisms, clinical relevance, and strategies for prevention.对有机硝酸盐的耐受性：证据、机制、临床相关性及预防策略。
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