尼古丁对家兔肌肉器官（回盲括约肌）的作用。
Action of nicotine on the rabbit muscular organ (ileo-colic sphincter).
作者信息
JARRETT R J
出版信息
Br J Pharmacol Chemother. 1962 Apr;18(2):397-404. doi: 10.1111/j.1476-5381.1962.tb01419.x.
The effects of nicotine on the longitudinal muscle of the rabbit muscular organ (ileo-colic sphincter) have been studied. Nicotine in doses from 1 to 10 mug/ml. inhibits the pendular movements of the muscle. This inhibition can also be produced by acetylcholine in the presence of atropine. In both instances, the inhibitory effect can be blocked by ephedrine, hexamethonium and bretylium. Doses of hexamethonium which block the inhibitory action of nicotine reveal an excitatory action, which itself can be blocked by higher doses of hexamethonium. Bretylium blocks both actions of nicotine at the same dose level. It is suggested that nicotine produces inhibition by releasing catechol amines, the site of action being a cholinergic junction between sympathetic nerve and catechol amine store, and further that bretylium blocks the action of acetylcholine and nicotine at this site as well as at the parasympathetic ganglia.
已经研究了尼古丁对家兔肌肉器官（回盲括约肌）纵肌的作用。剂量为1至10微克/毫升的尼古丁可抑制该肌肉的摆动运动。在阿托品存在的情况下，乙酰胆碱也可产生这种抑制作用。在这两种情况下，麻黄碱、六甲铵和溴苄铵均可阻断这种抑制作用。能阻断尼古丁抑制作用的六甲铵剂量会显示出兴奋作用，而更高剂量的六甲铵本身又可阻断这种兴奋作用。溴苄铵在相同剂量水平下可阻断尼古丁的两种作用。有人提出，尼古丁通过释放儿茶酚胺产生抑制作用，作用部位是交感神经与儿茶酚胺储存之间的胆碱能接头，并且进一步认为溴苄铵在该部位以及副交感神经节处阻断乙酰胆碱和尼古丁的作用。
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