Crocker A D, Wilson K A
Br J Pharmacol. 1974 May;51(1):73-9. doi: 10.1111/j.1476-5381.1974.tb09634.x.
1 Acetylcholine and angiotensin elicit a contraction of guinea-pig ileum. The metabolic requirements for these actions have been investigated.2 The angiotensin-induced response was far more dependent upon the presence of glucose than was the response to acetylcholine.3 Anoxia and oxidative enzyme inhibition preferentially reduced the angiotensin-induced response.4 The significance of these results is discussed. It is concluded that the response to angiotensin is dependent upon an ATP source distinct from that required by the contractile process. It is further shown that this energy-dependent stage cannot be identified with the indirect, cholinergic component of the angiotensin response in this tissue.
1 乙酰胆碱和血管紧张素可引起豚鼠回肠收缩。已对这些作用的代谢需求进行了研究。
2 血管紧张素诱导的反应比乙酰胆碱诱导的反应对葡萄糖的存在更具依赖性。
3 缺氧和氧化酶抑制优先降低血管紧张素诱导的反应。
4 讨论了这些结果的意义。得出的结论是，对血管紧张素的反应依赖于与收缩过程所需的ATP来源不同的ATP来源。进一步表明，这个能量依赖阶段与该组织中血管紧张素反应的间接胆碱能成分不一致。
