Hynynen M, Kupari M, Salmenperä M, Koskinen P, Tikkanen I, Fyhrquist F
Department of Anaesthesia, Helsinki University Central Hospital, Finland.
Alcohol Alcohol. 1992 May;27(3):277-85.
The present study was designed to test whether ethanol ingestion affects plasma atrial natriuretic factor (ANF) concentration in healthy volunteers. On the basis of previous studies showing that ethanol induces a diuretic response and a decrease in atrial size (atrial distension), it was hypothesized that ethanol intake might be associated with a decrease in plasma ANF level. To somewhat increase plasma ANF level, the subjects were slightly loaded with water before the trial. As compared with juice, ethanol, 1 g/kg within 1 hr, increased urine output [405 +/- 37 (mean +/- SEM) ml/hr vs. 197 +/- 20 ml/hr, P less than 0.001]. Left atrial size decreased similarly (P less than 0.001) with both drinks. Plasma ANF concentration did not change with either ethanol or juice during the 3-hr study period. No changes were observed in plasma arginine vasopressin concentration and plasma renin activity. Our results are in conflict with previous reports in fasted subjects showing significant changes in plasma concentrations of the same hormones. Thus, the basal fluid balance seems to be crucial to the hormonal response to ethanol. The plasma concentrations of the hormones measured in this study do not directly explain the diuretic response to ethanol observed in slightly volume-loaded subjects.
本研究旨在测试健康志愿者摄入乙醇是否会影响血浆心钠素（ANF）浓度。基于先前的研究表明乙醇可诱导利尿反应并使心房大小减小（心房扩张），推测乙醇摄入可能与血浆ANF水平降低有关。为了在一定程度上提高血浆ANF水平，在试验前让受试者稍微多饮水。与果汁相比，1小时内摄入1g/kg乙醇会增加尿量[405±37（均值±标准误）ml/小时对197±20ml/小时，P<0.001]。两种饮品都会使左心房大小同样减小（P<0.001）。在3小时的研究期间，血浆ANF浓度无论是乙醇组还是果汁组均未发生变化。血浆精氨酸加压素浓度和血浆肾素活性也未观察到变化。我们的结果与先前关于禁食受试者的报道相矛盾，那些报道显示相同激素的血浆浓度有显著变化。因此，基础液体平衡似乎对激素对乙醇的反应至关重要。本研究中测量的激素血浆浓度并不能直接解释在轻度容量负荷受试者中观察到的对乙醇的利尿反应。
