Guly U, Driscoll P
University Department of Accident and Emergency Medicine, Hope Hospital, Salford.
Arch Emerg Med. 1992 Sep;9(3):317-22. doi: 10.1136/emj.9.3.317.
Given the potential toxicity of even a small number of quinine tablets we suggest that patients to whom these are prescribed should be alerted to this risk both by the prescribing clinician and by a warning, clearly printed on the tablet container. There is no evidence that increased retinal arteriolar dilation is of any value in the management of patients with quinine induced blindness. Therefore the use of SGB for this condition must be questioned unless a controlled trial is performed which shows benefits. We recommend that the aim of treatment has to be reduction in the plasma level of quinine. The most efficient way of accomplishing this is by repeated oral activated charcoal.
鉴于即使少量奎宁片也存在潜在毒性，我们建议，对于开具了这些药物的患者，开处方的临床医生以及片剂容器上清晰印制的警告都应提醒他们注意这一风险。没有证据表明视网膜小动脉扩张加剧对奎宁所致失明患者的治疗有任何价值。因此，除非进行显示有益效果的对照试验，否则必须质疑将星状神经节阻滞用于这种情况的做法。我们建议治疗的目标必须是降低奎宁的血浆水平。实现这一目标的最有效方法是反复口服活性炭。
