Canning C R, Hague S
Moorfields Eye Hospital, London.
Br J Ophthalmol. 1988 Jan;72(1):23-6. doi: 10.1136/bjo.72.1.23.
A case of ocular quinine toxicity is described which showed the typical acute visual loss and subsequent recovery. Vermiform motion of the pupil was noted 48 hours after overdose. This acute effect has not been reported before. Although acute systemic intoxication may respond to removal of quinine from the gut and circulation, there is no evidence that any treatment affects the visual prognosis. The action of quinine on the retina is unknown. We suggest it may block cholinergic neurotransmission in the inner synaptic layer.
本文描述了一例眼部奎宁中毒病例，该病例表现出典型的急性视力丧失及随后的恢复情况。过量用药48小时后观察到瞳孔呈蠕动样运动。这种急性效应此前未见报道。尽管急性全身中毒可能通过清除肠道及循环中的奎宁而缓解，但尚无证据表明任何治疗方法会影响视力预后。奎宁对视网膜的作用尚不清楚。我们认为它可能会阻断内突触层的胆碱能神经传递。
