Bosma M J
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111.
Immunodefic Rev. 1992;3(4):261-76.
Recombination of antigen receptor gene elements (V, D and J) that code for Ig and TCR variable regions is defective in the scid mouse mutant. However, the defect is not absolute. Developing scid lymphocytes occasionally succeed in forming a productive VDJ and VJ rearrangement at two critical loci (e.g., IgH/IgL or TCR beta/TCR alpha), and given the appropriate stimuli, differentiate into clones of functional B or T cells. Scid mice with detectable B and/or T lymphocytes are referred to as leaky. This review considers the nature and possible basis of B and T cell leakiness in scid mice.
在严重联合免疫缺陷（scid）小鼠突变体中，编码免疫球蛋白（Ig）和T细胞受体（TCR）可变区的抗原受体基因元件（V、D和J）的重组存在缺陷。然而，这种缺陷并非绝对。发育中的scid淋巴细胞偶尔会成功地在两个关键位点（如IgH/IgL或TCRβ/TCRα）形成有效的VDJ和VJ重排，并且在受到适当刺激后，分化为功能性B细胞或T细胞克隆。具有可检测到的B和/或T淋巴细胞的scid小鼠被称为渗漏型。本综述探讨了scid小鼠中B细胞和T细胞渗漏的本质及可能的基础。
