用于人脑[11C]氟马西尼动力学分析的图像衍生输入函数。
Image-derived input function for [11C]flumazenil kinetic analysis in human brain.
作者信息
Sanabria-Bohórquez Sandra M, Maes Alex, Dupont Patrick, Bormans Guy, de Groot Tjibbe, Coimbra Alexandre, Eng WaiSi, Laethem Tine, De Lepeleire Inge, Gambale Jay, Vega Jose M, Burns H Donald
机构信息
Imaging Research, Merck Research Laboratories, West Point, PA, USA
出版信息
Mol Imaging Biol. 2003 Mar-Apr;5(2):72-8. doi: 10.1016/s1536-1632(03)00046-5.
PURPOSE
We describe a method for analysis of [11C]flumazenil data using an input curve directly derived from the positron emission tomography (PET) images.
PROCEDURE
The shape of the tracer plasma curve was obtained from the product of the intact flumazenil fraction in plasma in six arterial samples and the internal carotid artery time-activity curve (TAC). The resulting curve was calibrated using the [11C]flumazenil concentration in three of the six samples. The curve peak was recovered by adding an exponential function to the scaled curve whose parameters were estimated from simultaneous fittings of several tissue TACs assuming that all regions share the same input.
RESULTS
Good agreement was found between the image-derived and the experimental plasma curves in six subjects. Distribution volumes were highly correlated with linear regression slope and intercept values between [0.94, 1.03] and [-0.10, 0.16], respectively.
CONCLUSION
The proposed method is suitable for benzodiazepine receptor quantification requiring only a few blood samples.
目的
我们描述了一种使用直接从正电子发射断层扫描（PET）图像得出的输入曲线来分析[11C]氟马西尼数据的方法。
程序
示踪剂血浆曲线的形状是通过六个动脉样本中血浆中完整氟马西尼分数与颈内动脉时间-活性曲线（TAC）的乘积获得的。所得曲线使用六个样本中的三个样本中的[11C]氟马西尼浓度进行校准。通过向缩放后的曲线添加指数函数来恢复曲线峰值，该指数函数的参数是在假设所有区域共享相同输入的情况下，从几个组织TAC的同步拟合中估计出来的。
结果
在六名受试者中，发现图像衍生的血浆曲线与实验血浆曲线之间具有良好的一致性。分布体积分别与线性回归斜率和截距值高度相关，线性回归斜率和截距值分别在[0.94, 1.03]和[-0.10, 0.16]之间。
结论
所提出的方法适用于仅需要少量血样的苯二氮䓬受体定量分析。
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