Kurdziel Karen A, Figg William D, Carrasquillo Jorge A, Huebsch Susan, Whatley Millie, Sellers David, Libutti Steven K, Pluda James M, Dahut William, Reed Edward, Bacharach Stephen L
The Clinical Center, Molecular Imaging Center, Virginia Commonwealth University, Richmond, VA, USA.
Mol Imaging Biol. 2003 Mar-Apr;5(2):86-93. doi: 10.1016/s1536-1632(03)00039-8.
Monitoring of androgen independent prostate cancer (AIPC) therapy involves monitoring prostate specific antigen (PSA) blood serum concentrations; however, the reliability of small changes in PSA values has been questioned. We performed a small pilot study to determine whether PET might be a useful monitor of changes during anti-angiogenic therapy in AIPC.
Changes in tumor blood flow ([15O] water), blood volume ([11C]CO), 2-deoxy-2-[18F]fluoro-D-glucose (FDG) uptake and metabolic volume were measured before and during thalidomide treatment and compared with changes in PSA in six patients with AIPC.
The percent change in PSA correlated with the FDG Delta%SUV(mean) (r=0.94, P<0.01) and Delta%metabolic tumor volume (r=0.91, P<0.01) but less well with Delta%blood volume (r=0.65, P=0.14). Percent change blood flow values showed an inverse correlation with percent changes in PSA (r=-0.83, P=0.032).
PET measures of tumor blood flow and metabolism may have use in monitoring the physiologic changes occurring during anti-angiogenic therapy in AIPC.
雄激素非依赖性前列腺癌（AIPC）治疗的监测涉及监测前列腺特异性抗原（PSA）血清浓度；然而，PSA值微小变化的可靠性受到质疑。我们开展了一项小型初步研究，以确定PET是否可能是AIPC抗血管生成治疗期间变化的有用监测手段。
在沙利度胺治疗前和治疗期间，测量了6例AIPC患者的肿瘤血流（[15O]水）、血容量（[11C]CO）、2-脱氧-2-[18F]氟-D-葡萄糖（FDG）摄取和代谢体积的变化，并与PSA的变化进行比较。
PSA的变化百分比与FDG Δ%SUV（均值）相关（r = 0.94，P < 0.01）和Δ%代谢肿瘤体积相关（r = 0.91，P < 0.01），但与Δ%血容量相关性较差（r = 0.65，P = 0.14）。血流值变化百分比与PSA变化百分比呈负相关（r = -0.83，P = 0.032）。
PET对肿瘤血流和代谢的测量可能有助于监测AIPC抗血管生成治疗期间发生的生理变化。
