Department of Nuclear Medicine Recep Tayyip Erdoğan University School of Medicine, Rize, Turkey.
Department of Radiology, Ankara University School of Medicine, Ibni Sina Hospital, Ankara, Turkey.
Diagn Interv Radiol. 2021 Mar;27(2):275-282. doi: 10.5152/dir.2021.20016.
We aimed to investigate whether there is a correlation between dual-energy spectral computed tomography (DESCT) and 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) parameters in primary tumor and metastatic lymph nodes in patients with newly diagnosed lung cancer.
Primary tumor and metastatic lymph nodes of 68 patients diagnosed with lung cancer were evaluated retrospectively with 18F-FDG PET/CT and DESCT imaging. The histologic subtypes were adenocarcinoma (n=29), squamous cell carcinoma (SCC) (n=26), small cell lung cancer (SCLC) (n=11), and large cell neuroendocrine cancer (LCNEC) (n=2). In terms of PET parameters, SUVmax, SUVmean, SULmax, SULmean, SULpeak, and normalized SUL values were obtained for primary tumors and metastatic lymph nodes. In terms of DESCT parameters, maximum and mean iodine content (IC), normalized IC values, iodine enhancement (IE) and normalized IE values were calculated.
We found no correlation between DESCT and 18F-FDG PET/CT parameters in primary tumors and metastatic lymph nodes. In addition, no correlation was found in the analysis performed in any of the histologic subgroups. In patients with a primary tumor <3 cm, there was a moderate negative correlation between the parameters SUVmax-ICmax (r= -0.456, p = 0.043), SUVmean-ICmax (r= -0.464, p = 0.039) SULmean-ICmax (r= -0.497, p = 0.026), SUVmax-ICmean (r= -0.527, p = 0.020), SULmean-ICmean (r= -0.499, p = 0.025), and SULpeak-ICmean (r= -0.488, p = 0.029).
We consider that DESCT and 18F-FDG PET/CT indicate different characteristics of the tumors and should not supersede each other.
本研究旨在探讨在初诊肺癌患者中，原发肿瘤和转移性淋巴结的双能光谱 CT（DESCT）与 18F-氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（18F-FDG PET/CT）参数之间是否存在相关性。
回顾性分析 68 例初诊肺癌患者的 18F-FDG PET/CT 和 DESCT 影像学表现。组织学亚型包括腺癌（n=29）、鳞状细胞癌（SCC）（n=26）、小细胞肺癌（SCLC）（n=11）和大细胞神经内分泌癌（LCNEC）（n=2）。在 PET 参数方面，获取原发肿瘤和转移性淋巴结的 SUVmax、SUVmean、SULmax、SULmean、SULpeak 和归一化 SUL 值。在 DESCT 参数方面，计算最大和平均碘含量（IC）、归一化 IC 值、碘增强（IE）和归一化 IE 值。
我们发现原发肿瘤和转移性淋巴结的 DESCT 与 18F-FDG PET/CT 参数之间无相关性。此外，在任何组织学亚组的分析中均未发现相关性。在原发肿瘤<3cm 的患者中，SUVmax-ICmax（r= -0.456，p = 0.043）、SUVmean-ICmax（r= -0.464，p = 0.039）、SULmean-ICmax（r= -0.497，p = 0.026）、SUVmax-ICmean（r= -0.527，p = 0.020）、SULmean-ICmean（r= -0.499，p = 0.025）和 SULpeak-ICmean（r= -0.488，p = 0.029）参数之间存在中度负相关。
我们认为 DESCT 和 18F-FDG PET/CT 提示肿瘤具有不同的特征，不应相互替代。
