Raja Srikumar M, Metkar Sunil S, Froelich Christopher J
Department of Medicine, Evanston Northwestern Healthcare Research Institute, 2650 Ridge Avenue, Evanston, IL 60201, USA.
Curr Opin Immunol. 2003 Oct;15(5):528-32. doi: 10.1016/s0952-7915(03)00111-0.
The molecular details of cytotoxic granule-mediated apoptosis have been gleaned from the study of the effects of isolated granzymes and perforin on target cells. Recent evidence indicates that the physiological apoptosis-inducing form is a multi-component macro-complex consisting of cationic granule proteins non-covalently linked to the chondroitin-sulfate proteoglycan, serglycin.
细胞毒性颗粒介导的细胞凋亡的分子细节已从对分离的颗粒酶和穿孔素对靶细胞作用的研究中收集到。最近的证据表明，生理上诱导细胞凋亡的形式是一种多组分的大复合物，由与硫酸软骨素蛋白聚糖、丝甘蛋白聚糖非共价连接的阳离子颗粒蛋白组成。
