Leung Siu-Kau, Ungvari Gabor S, Ng Fung-Shing, Cheung Hung-Kin, Leung Tony
Castle Peak Hospital, Tuen Mun, Hong Kong SAR, China.
Prog Neuropsychopharmacol Biol Psychiatry. 2003 Sep;27(6):1029-35. doi: 10.1016/S0278-5846(03)00171-4.
The objective of the study was to determine the point prevalence of tardive dyskinesia (TD) in Chinese inpatients with chronic schizophrenia and its association with sociodemographic, clinical and treatment variables and other movement disorders. A cross-sectional assessment of a randomly selected cohort of inpatients (n=225; mean age=42+/-7 years) with DSM-IV schizophrenia was employed using standard rating instruments for TD and other drug-induced movement disorders, in addition to catatonia, and psychotic, negative, depressive and obsessive-compulsive symptoms. Using Schooler and Kane's criteria, 15 subjects (6.7%) had TD. Patients with TD were significantly older and significantly fewer of them were taking antiparkinsonian medication than subjects without TD. There was no significant difference between the TD and non-TD groups with respect to other demographic, clinical and treatment variables including sex, age of onset, length of contact with psychiatric services, current antipsychotic dosage, negative symptoms, catatonia and parkinsonism. The results confirmed the low prevalence of TD in patients with chronic schizophrenia compared to those found in Caucasian patients. The study has also replicated the association of TD in Chinese schizophrenia patients with older age but failed to demonstrate any association between TD and other demographic or clinical characteristics including catatonia.
该研究的目的是确定中国慢性精神分裂症住院患者中迟发性运动障碍（TD）的时点患病率，及其与社会人口学、临床和治疗变量以及其他运动障碍的关联。采用标准评定工具，对随机选取的一组符合《精神疾病诊断与统计手册》第四版（DSM-IV）精神分裂症诊断标准的住院患者（n = 225；平均年龄 = 42±7岁）进行横断面评估，以评定TD及其他药物所致运动障碍，此外还评估紧张症、精神病性症状、阴性症状、抑郁症状和强迫症状。按照斯库勒（Schooler）和凯恩（Kane）的标准，15名受试者（6.7%）患有TD。与无TD的受试者相比，患有TD的患者年龄显著更大，且服用抗帕金森药物的人数显著更少。在其他人口学、临床和治疗变量方面，包括性别、起病年龄、与精神科服务机构接触的时长、当前抗精神病药物剂量、阴性症状、紧张症和帕金森症，TD组与非TD组之间无显著差异。结果证实，与高加索患者相比，慢性精神分裂症患者中TD的患病率较低。该研究还重现了中国精神分裂症患者中TD与年龄较大之间的关联，但未证明TD与包括紧张症在内的其他人口学或临床特征之间存在任何关联。
