Ahmed Alsir A M, Graham Alastair N J, Lovell Deirdre, O'Kane Hugh O
Department of Cardiac Surgery, Royal Victoria Hospital, Belfast, UK.
Eur J Cardiothorac Surg. 2003 Oct;24(4):535-9; discussion 539-40. doi: 10.1016/s1010-7940(03)00469-x.
The long term survival of patients with mild to moderate aortic valve disease who do not have valve replacement at the time of coronary artery bypass grafting (CABG) is unknown. Therefore we have reviewed our experience with such patients.
We reviewed the medical records of consecutive patients between June 1978 and December 1996, and identified 40 patients with mild to moderate aortic valve disease, who underwent CABG, without valve replacement (study group). Mean preoperative aortic gradient was 34 mmHg and mean intraoperative gradient 20 mmHg. Eleven patients underwent valve inspection, and an equal number, underwent valve repair. The records of 61 other patients with severe aortic valve disease, who underwent concomitant aortic valve replacement (AVR) and CABG (control group), were also reviewed.
Survival was significantly better in the control group. Eleven patients (27.5%) in the study group underwent reoperation for AVR, with no operative mortality. Multivariate analysis confirmed valve replacement at initial CABG to be the only predictor of survival (beta=0.586,P=0.038) Preoperative gradient <40 mmHg, intraoperative gradient <20 mmHg, age over 70, sex, aortic stenosis and valve pathology did not predict survival in the study group.
Patients with mild to moderate aortic valve disease undergoing coronary artery bypass grafting may be best served by valve replacement, rather than repair, inspection or no procedure.
对于轻至中度主动脉瓣疾病患者,在冠状动脉旁路移植术(CABG)时未进行瓣膜置换,其长期生存率尚不清楚。因此,我们回顾了对此类患者的治疗经验。
我们回顾了1978年6月至1996年12月期间连续患者的病历,确定了40例轻至中度主动脉瓣疾病患者,他们接受了CABG但未进行瓣膜置换(研究组)。术前平均主动脉压差为34 mmHg,术中平均压差为20 mmHg。11例患者接受了瓣膜检查,同样数量的患者接受了瓣膜修复。还回顾了另外61例重度主动脉瓣疾病患者的病历,他们同时接受了主动脉瓣置换(AVR)和CABG(对照组)。
对照组的生存率明显更高。研究组中有11例患者(27.5%)因AVR接受了再次手术,无手术死亡。多因素分析证实初次CABG时进行瓣膜置换是生存的唯一预测因素(β=0.586,P=0.038)。术前压差<40 mmHg、术中压差<20 mmHg、年龄超过70岁、性别、主动脉狭窄和瓣膜病变在研究组中均不能预测生存情况。
接受冠状动脉旁路移植术的轻至中度主动脉瓣疾病患者,进行瓣膜置换可能比瓣膜修复、检查或不进行任何操作更有益。