Rupp Richard E, Rosenthal Susan L
Department of Pediatrics, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Curr Opin Obstet Gynecol. 2003 Oct;15(5):371-5. doi: 10.1097/00001703-200310000-00004.
Sexually active teens are at significant risk from sexually transmitted infections and girls and women bear the greatest burden of these infections. New methods, such as vaginal microbicides, would provide female controlled options. Microbicides are currently in development and thus it is timely to discuss the progress made and factors that may influence acceptability for teens.
Microbicide development presents many challenges, and several different potential mechanisms of action are being explored. There is interest in these products from women and men, and specific preferences are being investigated. Adolescents, due to reproductive system immaturity, developing cognitive abilities and the psychosocial context of their relationships, present a special set of challenges in efforts to foster microbicide use.
Vaginal microbicides are on the horizon. Further study into teen issues is required to develop successful strategies for marketing and encouraging adolescent use of microbicides.
性活跃的青少年面临性传播感染的重大风险，女孩和妇女承担着这些感染的最大负担。新方法，如阴道杀菌剂，将提供女性可控的选择。目前杀菌剂正在研发中，因此讨论所取得的进展以及可能影响青少年接受度的因素恰逢其时。
杀菌剂的研发面临诸多挑战，正在探索几种不同的潜在作用机制。男性和女性对这些产品都感兴趣，正在研究他们的具体偏好。由于生殖系统不成熟、认知能力发展以及其人际关系的社会心理背景，青少年在促进杀菌剂使用方面面临一系列特殊挑战。
阴道杀菌剂即将问世。需要进一步研究青少年问题，以制定成功的营销策略并鼓励青少年使用杀菌剂。
