Rosenthal S L, Cohen S S, Stanberry L R
Department of Pediatrics, University of Cincinnati College of Medicine, Ohio, USA.
Sex Transm Dis. 1998 Aug;25(7):368-77. doi: 10.1097/00007435-199808000-00009.
For sexually active adolescent girls, sexually transmitted diseases (STDs) represent a significant health problem. Although condom use may be an effective intervention against STDs in this high-risk population, actual use depends on the cooperation of the male partner. Therefore, the development of female-controlled methods such as topical microbicides have been endorsed as an important option for STD prevention.
This article reviews the current status of intravaginal microbicide development and discusses aspects of adolescent development that should be considered in topical microbicide research.
Biological development, cognitive capacities, psychosexual maturation, and the sociocultural context are key features that affect the likelihood that adolescents will adopt microbicides as a specific methods of STD protection.
Adoption of topical microbicides by adolescents will require an "adolescent friendly" perspective for topical microbicides to have a significant impact on the STD epidemic.
对于性活跃的青春期女孩而言，性传播疾病（STD）是一个重大的健康问题。尽管使用避孕套可能是针对这一高风险人群预防性传播疾病的有效干预措施，但实际使用情况取决于男性伴侣的配合。因此，开发诸如局部杀菌剂等女性可控的方法已被认可为预防性传播疾病的重要选择。
本文综述了阴道内杀菌剂开发的现状，并讨论了局部杀菌剂研究中应考虑的青春期发育方面的问题。
生物学发育、认知能力、性心理成熟以及社会文化背景是影响青少年将杀菌剂作为预防性传播疾病特定方法的可能性的关键因素。
青少年采用局部杀菌剂将需要从“适合青少年”的角度出发，以使局部杀菌剂对性传播疾病的流行产生重大影响。
