McNamara Patrick, Durso Raymon, Brown Ariel
Department of Neurology, Boston University School of Medicine, Boston, MA 02130, USA.
Cogn Behav Neurol. 2003 Sep;16(3):139-48. doi: 10.1097/00146965-200309000-00001.
Recent reports have linked impairment of various aspects of the sense of self to frontal brain dysfunction. Independent evidence suggests that patients with Parkinson's disease exhibit impairment on cognitive tasks that depend on the frontal lobes.
To test the hypothesis (1) that the sense of self would be impaired in some persons with Parkinson's disease and (2) that this impairment would be linked to frontal dysfunction.
Sentence completion tests of identity development ("self-test") and measures of frontal and temporal lobe functioning were administered to 20 people with Parkinson's disease and to 10 age-matched healthy controls.
While self-test responses significantly correlated with performance scores on tests of executive function (for Parkinson's disease patients only) but not temporal lobe function (as measured by "clustering" rates on a fluency task), we found no significant differences in mean self-test scores between persons with Parkinson's disease and age-matched controls. Analysis of the 160 self-test responses revealed a shift toward conformist responses in Hoehn-Yahr stage III as compared with stage II Parkinson's disease patients.
While the sense of self changes as a function of disease stage, the core experience of self in Parkinson's disease is intact but may depend, in part, on frontal lobe function.
近期报告将自我意识各方面的损害与额叶脑功能障碍联系起来。独立证据表明，帕金森病患者在依赖额叶的认知任务上表现出损害。
检验以下假设：（1）部分帕金森病患者的自我意识会受损；（2）这种损害与额叶功能障碍有关。
对20名帕金森病患者和10名年龄匹配的健康对照者进行身份发展的句子完成测试（“自我测试”）以及额叶和颞叶功能测量。
虽然自我测试反应与执行功能测试的表现得分显著相关（仅针对帕金森病患者），但与颞叶功能无关（通过流畅性任务的“聚类”率测量），我们发现帕金森病患者与年龄匹配的对照者之间的平均自我测试得分没有显著差异。对160份自我测试反应的分析显示，与帕金森病Ⅱ期患者相比，Ⅲ期患者的反应向从众反应转变。
虽然自我意识随疾病阶段而变化，但帕金森病患者的核心自我体验是完整的，但可能部分依赖于额叶功能。
