Dessanti Antonio, Iannuccelli Marco, Ginesu Giorgio, Feo Claudio
Unit of Pediatric Surgery, Department of Surgery, University of Sassari, Italy.
J Urol. 2003 Oct;170(4 Pt 2):1600-2. doi: 10.1097/01.ju.0000083925.07074.32.
The most common techniques to reconstruct the urethra for severe hypospadias or epispadias involve use of the genital skin. Buccal mucosa free graft is usually used in a second operation due to a paucity of usable genital tissue. We report our experience using buccal mucosa free graft as primary surgery for hypospadias and epispadias.
Between 1989 and 2001 the urethra was reconstructed using buccal mucosa free graft as a primary operation in 22 patients 3 to 13 years old with middle or proximal hypospadias (20) and exstrophy/epispadias (2). In the first 5 cases of hypospadias the buccal mucosa was combined with bladder mucosa. In the 2 exstrophy/epispadias cases treated with the penile disassembly technique the distal part of the urethra was reconstructed with buccal mucosa.
At mean 5-year followup 2 cases of urethral fistulas and 1 case of severe stenosis of the proximal anastomosis were observed, which required surgical correction. In 4 other cases mild stenosis of the anastomosis required urethral dilations in the first month after surgery.
Buccal mucosa is an excellent source of graft material for urethral replacement in complex urethroplasties as primary surgery. It is readily available, elastic, resistant and technically easy to harvest.
重建重度尿道下裂或尿道上裂尿道的最常用技术涉及使用生殖器皮肤。由于可用的生殖器组织较少,颊黏膜游离移植通常在二次手术中使用。我们报告了我们使用颊黏膜游离移植作为尿道下裂和尿道上裂一期手术的经验。
1989年至2001年间,对22例3至13岁患有中或近端尿道下裂(20例)和膀胱外翻/尿道上裂(2例)的患者,使用颊黏膜游离移植进行尿道一期重建。在前5例尿道下裂病例中,颊黏膜与膀胱黏膜联合使用。在2例采用阴茎解体技术治疗的膀胱外翻/尿道上裂病例中,尿道远端用颊黏膜重建。
平均5年随访时,观察到2例尿道瘘和1例近端吻合口严重狭窄,需要手术矫正。在其他4例中,吻合口轻度狭窄在术后第一个月需要进行尿道扩张。
颊黏膜是复杂尿道成形术中作为一期手术进行尿道替代的优良移植物来源。它容易获取、有弹性、耐用且在技术上易于采集。