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[颊黏膜在尿道手术中的应用]

[Use of buccal mucosa in urethral surgery].

作者信息

Stein R, Schröder A, Thüroff J W

机构信息

Urologische Klinik und Poliklinik, Klinikum der Johannes-Gutenberg-Universität, Langenbeck-Strasse 1, Mainz, Germany.

出版信息

Urologe A. 2007 Dec;46(12):1657-63. doi: 10.1007/s00120-007-1587-z.

Abstract

Buccal mucosa grafts have proven reliable in urethral surgery. For augmentation urethroplasty, the graft can be used as a ventral or dorsal onlay. If the graft was used as an onlay, the results were much better than in substitution urethroplasty with the graft used as a tube. In patients with complex strictures or severe cases of hypospadias or epispadias, a two-stage technique using a buccal mucosa inlay graft can be applied. After 6 months, the well-revascularized buccal mucosa strip can be tubularized and covered with a tunica dartos or tunica vaginalis flap. In the future, for correction of larger defects, buccal mucosa cells can be cultured in vitro on biodegradable matrices. These larger buccal mucosa transplants could minimize the morbidity at the donor site. Future studies must clarify if the new technology of nanofibers can be of advantage by producing better matrices.

摘要

颊黏膜移植物在尿道手术中已被证明是可靠的。对于尿道成形术,移植物可用于腹侧或背侧覆盖。如果移植物用作覆盖物,其效果比将移植物用作管道的替代尿道成形术要好得多。对于复杂狭窄、重度尿道下裂或尿道上裂患者,可采用两阶段技术,使用颊黏膜内嵌移植物。6个月后,血管化良好的颊黏膜条可制成管状,并用肉膜或鞘膜瓣覆盖。未来,为了修复更大的缺损,颊黏膜细胞可在体外的可生物降解基质上培养。这些更大的颊黏膜移植物可将供区的发病率降至最低。未来的研究必须阐明纳米纤维新技术是否能通过生产更好的基质而具有优势。

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