Galli Massimo, Veglia Fabrizio, Angarano Gioacchino, Santambrogio Sara, Meneghini Elena, Gritti Francesco, Cargnel Antonietta, Mazzotta Francesco, Lazzarin Adriano
Institute of Infectious and Tropical Diseases, University of Milan, Italy.
J Acquir Immune Defic Syndr. 2003 Sep 1;34(1):58-61. doi: 10.1097/00126334-200309010-00008.
Adipose tissue alterations (ATAs) were clinically assessed in 2258 HIV-1-infected outpatients consecutively observed in 6 Italian clinical centers and were found to be present in 29.5% of the men and 41.9% of the women. A logistic regression model including age, HIV disease Centers for Disease Control stage, CD4 cell counts, HIV RNA load, the duration of antiretroviral therapy, the number of drugs taken, and the use of d4T showed that men had a 0.47 adjusted risk of presenting with ATAs (95% CI: 0.38-0.58, P < 0.0001). The risks of having ATAs (except circumscribed lipomas) in any body region, presenting with fat accumulation, or being affected by combined forms of ATA were also lower in men, whereas the risk of developing pure lipoatrophy was similar in the 2 genders. Our results indicate that women are at higher risk of developing antiretroviral treatment-related ATAs and show a particular and complex ATA pattern.
在意大利6个临床中心对2258名接受连续观察的HIV-1感染门诊患者的脂肪组织改变（ATA）进行了临床评估，结果发现29.5%的男性和41.9%的女性存在这种改变。一个逻辑回归模型纳入了年龄、HIV疾病美国疾病控制中心分期、CD4细胞计数、HIV RNA载量、抗逆转录病毒治疗持续时间、用药数量以及司他夫定（d4T）的使用情况，结果显示男性出现ATA的校正风险为0.47（95%置信区间：0.38 - 0.58，P < 0.0001）。男性在身体任何部位出现ATA（除局限性脂肪瘤外）、出现脂肪堆积或受ATA联合形式影响的风险也较低，而发生单纯性脂肪萎缩的风险在两性中相似。我们的结果表明，女性发生抗逆转录病毒治疗相关ATA的风险更高，并且呈现出一种特殊且复杂的ATA模式。
