Condray R, Steinhauer S R, Goldstein G
Highland Drive VA Medical Center, Pittsburgh, PA 15206.
Biol Psychiatry. 1992 Nov 1;32(9):790-802. doi: 10.1016/0006-3223(92)90082-b.
Disturbances in language functioning may be associated with familial vulnerability to schizophrenia. Language comprehension, measured by the Luria-Nebraska Relational Concepts Factor Scale, was evaluated in 36 schizophrenic probands and their nonschizophrenic adult brothers (n = 41), and in 18 normal controls. Language comprehension performance was a function of psychiatric diagnosis in the brothers. Brothers who met criteria for schizophrenia-spectrum disorders showed significantly reduced language performance compared with unaffected brothers and normal controls. Moreover, abnormal language performance was exhibited by significantly more probands and spectrum-disordered brothers than by the normal controls and the brothers without schizophrenia-spectrum disorders. Finally, language performance was not significantly different for 31 pairs of schizophrenic probands and their brothers. Impaired language comprehension appeared comparatively specific in this sample of relatives, as groups were not significantly different on measures of nonlinguistic concept formation (Wisconsin Card Sorting Test) and general intellectual functioning (WAIS-R Information and Block design). Results suggest that impaired language comprehension is associated with familial vulnerability to schizophrenia, and that this disturbance may be most severe in relatives diagnosed with schizophrenia-spectrum disorders.
语言功能障碍可能与家族性精神分裂症易感性有关。采用鲁利亚-内布拉斯加关系概念因子量表测量语言理解能力，对36名精神分裂症先证者及其非精神分裂症成年兄弟（n = 41）以及18名正常对照者进行了评估。语言理解能力是兄弟中精神疾病诊断的一个函数。符合精神分裂症谱系障碍标准的兄弟与未患病兄弟及正常对照相比，语言能力显著下降。此外，与正常对照和无精神分裂症谱系障碍的兄弟相比，先证者和患有谱系障碍的兄弟中出现异常语言能力的人数明显更多。最后，31对精神分裂症先证者及其兄弟的语言能力没有显著差异。在这个亲属样本中，语言理解受损似乎相对具有特异性，因为在非语言概念形成测量（威斯康星卡片分类测验）和一般智力功能测量（韦氏成人智力量表修订版信息和积木图案分测验）上，各组之间没有显著差异。结果表明，语言理解受损与家族性精神分裂症易感性有关，并且这种障碍在被诊断为精神分裂症谱系障碍的亲属中可能最为严重。
