Waters A H
Department of Haematology, St Bartholomew's Hospital, Medical College, West Smithfield, London, UK.
Blood Coagul Fibrinolysis. 1992 Oct;3(5):637-41. doi: 10.1097/00001721-199210000-00019.
An immune response to human platelet antigens (HPA), as in neonatal alloimmune thrombocytopenia (NAIT) and post-transfusion purpura (PTP), is the exception rather than the rule and evidence is accumulating for the importance of human leucocyte antigen (HLA) class II restriction in this situation. Platelets have only HLA class I antigens and do not cause primary HLA alloimmunization; in platelet transfusions this is due to the contaminating leucocytes. Autoimmune thrombocytopenia is more common than the alloimmune conditions. The main target antigens for platelet autoantibodies are glycoproteins (Gp) IIb/IIIa and Ib/IX. The mechanism of drug-induced immune thrombocytopenia has been re-examined in relation to the target cell orientation of the antibody and of the drug.
对人类血小板抗原（HPA）的免疫反应，如在新生儿同种免疫性血小板减少症（NAIT）和输血后紫癜（PTP）中，是个例外而非普遍规律，并且越来越多的证据表明在这种情况下人类白细胞抗原（HLA）II类限制的重要性。血小板仅具有HLA I类抗原，不会引起原发性HLA同种免疫；在血小板输注中，这是由于污染的白细胞所致。自身免疫性血小板减少症比同种免疫性疾病更为常见。血小板自身抗体的主要靶抗原是糖蛋白（Gp）IIb/IIIa和Ib/IX。药物诱导的免疫性血小板减少症的机制已根据抗体和药物的靶细胞方向重新进行了研究。
