针对血小板糖蛋白Ib/IX上的低频抗原Iy的同种免疫，是严重新生儿同种免疫性血小板减少性紫癜的一个病因。

Alloimmunization against Iy, a low-frequency antigen on platelet glycoprotein Ib/IX as a cause of severe neonatal alloimmune thrombocytopenic purpura.

作者信息

Kiefel V, Vicariot M, Giovangrandi Y, Kroll H, Böhringer M, Greinacher A, Breitfeld C, Santoso S, Mueller-Eckhardt C

机构信息

Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig University, Giessen, Germany.

出版信息

Vox Sang. 1995;69(3):250-4. doi: 10.1111/j.1423-0410.1995.tb02604.x.

DOI:10.1111/j.1423-0410.1995.tb02604.x

PMID:8578740

Abstract

Neonatal alloimmune thrombocytopenia (NAIT) is usually induced by platelet-specific antibodies against HPA-1a (Zwa) or HPA-5b (Bra). Recently, low-frequency alloantigens on the platelet glycoprotein (GP) IIb/IIIa complex have been discovered as a cause for NAIT. In this report, a new low-frequency platelet-specific alloantigen, Iy, is described which induced severe NAIT. The corresponding antigen was detected in 1/249 unrelated German blood donors. Antibody binding assays with trypsin-digested platelets (ELISA, immunoprecipitation with biotin-labelled platelets) indicate that the antigen is not localized on the glycocalicin moiety of GP Ib alpha, but may be situated on the remnant moiety of GP Ib alpha, GP IX or GPIb beta. Apparently, Iy is not related to the HPA-2 (Ko) antigen system.

摘要

新生儿同种免疫性血小板减少症（NAIT）通常由针对血小板特异性抗原HPA-1a（Zwa）或HPA-5b（Bra）的抗体所诱发。近来，已发现血小板糖蛋白（GP）IIb/IIIa复合物上的低频同种抗原是NAIT的病因之一。在本报告中，描述了一种新的低频血小板特异性同种抗原Iy，它可诱发严重的NAIT。在1/249名无亲缘关系的德国献血者中检测到了相应抗原。用胰蛋白酶消化血小板进行的抗体结合试验（ELISA、生物素标记血小板的免疫沉淀法）表明，该抗原并不定位于GP Ibα的糖萼部分，而可能位于GP Ibα、GP IX或GPIbβ的残余部分。显然，Iy与HPA-2（Ko）抗原系统无关。