Zuo P, Yu C, Wu R, Sui J
Institute of Basic Medical Sciences, CAMS, Beijing.
Chin Med Sci J. 1992 Jun;7(2):79-81.
The unilateral nigrostriatal pathway of rats was destroyed by microinjecting 6-hydroxydopamine (6-OH-DA), and isogenous rat adrenal medullary tissue was then transplanted into the lesioned lateral caudate nucleus. After 2 months, rotational movement was almost abolished in 40% of the transplanted rats, and it was significantly reduced in the remaining 60%. Dopamine (DA) and its metabolites contents were significantly decreased in the lesioned side of the forebrain, while no changes of NA were found. After transplanting adrenal medullary tissue, the DA contents increased by 9% only, whereas the NA contents increased significantly. In addition, by examining synaptosomes in the brains of these rats, we found that on the lesioned side of nontransplanted rats, DA uptake and DA receptor binding were increased significantly, while no such changes were seen in the transplanted group.
通过微量注射6-羟基多巴胺（6-OH-DA）破坏大鼠的单侧黑质纹状体通路，然后将同基因大鼠肾上腺髓质组织移植到受损的外侧尾状核中。2个月后，40%的移植大鼠的旋转运动几乎消失，其余60%的大鼠旋转运动明显减少。前脑损伤侧的多巴胺（DA）及其代谢产物含量显著降低，而去甲肾上腺素（NA）含量未见变化。移植肾上腺髓质组织后，DA含量仅增加了9%，而NA含量显著增加。此外，通过检测这些大鼠大脑中的突触体，我们发现未移植大鼠的损伤侧，DA摄取和DA受体结合显著增加，而移植组未见此类变化。
