Flachenecker P, Rufer A, Bihler I, Hippel C, Reiners K, Toyka K V, Kesselring J
Department of Neurology, Julius-Maximilians-Universität, Würzburg, Germany.
Neurology. 2003 Sep 23;61(6):851-3. doi: 10.1212/01.wnl.0000080365.95436.b8.
The authors studied standard autonomic function tests and measures of heart rate variability in 60 patients with multiple sclerosis (MS) and correlated results with the Fatigue Severity Scale and the Modified Fatigue Impact Scale. The authors found that autonomic responses correlated with fatigue resembling a hypoadrenergic orthostatic response, possibly due to a sympathetic vasomotor lesion with intact vagal heart control. Treatments to control sympathetic dysfunction for MS-associated fatigue deserve further study.
作者对60例多发性硬化症（MS）患者进行了标准自主神经功能测试和心率变异性测量，并将结果与疲劳严重程度量表和改良疲劳影响量表进行了关联分析。作者发现，自主神经反应与类似低肾上腺素能直立反应的疲劳相关，这可能是由于交感神经血管运动损伤而迷走神经对心脏的控制完好所致。针对MS相关疲劳控制交感神经功能障碍的治疗值得进一步研究。
