Virtanen Raine, Jula Antti, Salminen Jouko K, Voipio-Pulkki Liisa-Maria, Helenius Hans, Kuusela Tom, Airaksinen Juhani
Department of Medicine, Turku University Central Hospital, Finland.
Psychosom Med. 2003 Sep-Oct;65(5):751-6. doi: 10.1097/01.psy.0000088760.65046.cf.
The purpose of this study was to determine whether psychological factors are associated with heart rate variability (HRV), blood pressure variability (BPV), and baroreflex sensitivity (BRS) among healthy middle-aged men and women.
A population-based sample of 71 men and 79 women (35-64 years of age) was studied. Five-minute supine recordings of ECG and beat-to-beat photoplethysmographic finger systolic arterial pressure and diastolic arterial pressure were obtained during paced breathing. Power spectra were computed using a fast Fourier transform for low-frequency (0.04-0.15 Hz) and high-frequency (0.15-0.40 Hz) powers. BRS was calculated by cross-spectral analysis of R-R interval and systolic arterial pressure variabilities. Psychological factors were evaluated by three self-report questionnaires: the Brief Symptom Inventory, the shortened version of the Spielberger State-Trait Anger Expression Inventory, and the Toronto Alexithymia Scale.
Psychological factors were not related to HRV. Anxiety was associated with decreased BRS (p = 0.001) and higher low-frequency (p = 0.002) power of systolic arterial pressure variability. These associations were independent of age, gender, other psychological factors, heart rate, and systolic and diastolic blood pressures. Hostility was an independent correlate of increased low-frequency power of diastolic arterial pressure (p = 0.001) and increased high-frequency power of systolic arterial pressure (p = 0.033) variability.
Anxiety and hostility are related to reduced BRS and increased low-frequency power of BPV. Reduced BRS reflects decreased parasympathetic outflow to the heart and may increase BPV through an increased sympathetic predominance.
本研究旨在确定心理因素是否与健康中年男性和女性的心率变异性（HRV）、血压变异性（BPV）和压力反射敏感性（BRS）相关。
对71名男性和79名女性（35 - 64岁）的基于人群的样本进行研究。在定频呼吸期间，获取5分钟仰卧位的心电图以及逐搏光电容积描记法测量的手指收缩期动脉压和舒张期动脉压记录。使用快速傅里叶变换计算低频（0.04 - 0.15赫兹）和高频（0.15 - 0.40赫兹）功率的功率谱。通过对R - R间期和收缩期动脉压变异性进行交叉谱分析来计算BRS。心理因素通过三份自我报告问卷进行评估：简明症状量表、斯皮尔伯格状态 - 特质愤怒表达量表的简化版以及多伦多述情障碍量表。
心理因素与HRV无关。焦虑与BRS降低（p = 0.001）以及收缩期动脉压变异性的低频功率升高（p = 0.002）相关。这些关联独立于年龄、性别、其他心理因素、心率以及收缩压和舒张压。敌意是舒张压低频功率升高（p = 0.001）和收缩期动脉压变异性高频功率升高（p = 0.033）的独立相关因素。
焦虑和敌意与BRS降低以及BPV的低频功率升高有关。BRS降低反映了心脏副交感神经传出减少，可能通过交感神经优势增加而导致BPV升高。
