Segev Fani, Jaeger-Roshu Simona, Gefen-Carmi Noa, Assia Ehud I
Department of Opthalmology, Meir Hospital, Sapir Medical Center, Kfar-Saba, Israel.
Cornea. 2003 Oct;22(7):598-603. doi: 10.1097/00003226-200310000-00003.
To evaluate the long-term postoperative outcome and complication rate of combined intraoperative low-dose mitomycin C application and free conjunctival autograft for the treatment of pterygium.
In a prospective, consecutive, noncomparative case series, a series of 46 consecutive patients (50 eyes) with primary pterygium (43 eyes) or recurrent pterygium (7 eyes) were studied. The patients' ages ranged from 23.0 to 80.0 years (mean, 53.4 years). All patients underwent pterygium excision combined with intraoperative low-dose mitomycin C application (0.02% for 2 minutes) and free conjunctival autograft. The mean follow-up period was 29.2 months (range 12 to 41 months). The main outcome measures were recurrence of pterygium and postoperative complications.
Pterygium recurred to a small extent (0.5 mm) in one eye (2%) of a patient with recurrent pterygium. There were no intraoperative complications. Subconjunctival graft hematoma appeared soon after surgery and resolved spontaneously in five eyes (10%). One eye developed transient high intraocular pressure without optic nerve or visual field defect, and one eye developed mild symblepharon. There were no sight-threatening complications or serious side effects.
By applying a single low dose of mitomycin C combined with free conjunctival autograft during pterygium excision, the recurrence rate of pterygium can be markedly reduced.
评估术中联合应用低剂量丝裂霉素C及游离结膜自体移植治疗翼状胬肉的术后长期疗效及并发症发生率。
在一项前瞻性、连续性、非对照病例系列研究中，对46例连续患者（50只眼）进行了研究，其中原发性翼状胬肉43只眼，复发性翼状胬肉7只眼。患者年龄范围为23.0至80.0岁（平均53.4岁）。所有患者均接受翼状胬肉切除联合术中低剂量丝裂霉素C应用（0.02%，2分钟）及游离结膜自体移植。平均随访期为29.2个月（范围12至41个月）。主要观察指标为翼状胬肉复发及术后并发症。
1例复发性翼状胬肉患者的1只眼（2%）翼状胬肉有轻度复发（0.5 mm）。术中无并发症。术后5只眼（10%）出现结膜下移植片血肿，且均自行消退。1只眼出现短暂性高眼压，但无视神经或视野缺损，1只眼出现轻度睑球粘连。无威胁视力的并发症或严重副作用。
在翼状胬肉切除术中应用单次低剂量丝裂霉素C联合游离结膜自体移植，可显著降低翼状胬肉的复发率。
