Gris Oscar, Del Campo Zoraida, Wolley-Dod Charlotte, Güell José L, Velasco Fortino, Adán Alfredo
Department of Ophtalmology, Hospital de la Santa Creu i Sant Pau, Universitat Autónoma de Barcelona, Barcelona, Spain.
Cornea. 2003 Oct;22(7):675-8. doi: 10.1097/00003226-200310000-00012.
To present a case of chemical injury associated with calcification and severe conjunctival and scleral ischemia, in which tissue regeneration was achieved using an amniotic membrane graft.
A 65-year-old man presented to our department 8 weeks after suffering a chemical injury of his left eye with sulfuric acid. There was extensive calcification of the cornea and conjunctiva, associated with severe ischemia of the adjacent sclera. After resection of the calcified tissue and nonviable tissue, amniotic membrane was grafted to cover the extensive zone of scleral ischemia.
In the weeks following grafting, slow epithelialization and revascularization was observed over the amniotic membrane, stemming from the surrounding healthy conjunctiva.
Although the presence of ischemia at the base of the graft has been considered a contraindication for amniotic membrane transplantation, this case demonstrates that, provided that the surrounding tissue is not affected, a graft may be useful. In such cases an amniotic membrane graft could be attempted before other alternatives, such as conjuntival or oral mucosal autografts.
报告一例伴有钙化及严重结膜和巩膜缺血的化学伤病例，该病例通过羊膜移植实现了组织再生。
一名65岁男性在左眼遭受硫酸化学伤8周后就诊于我科。角膜和结膜存在广泛钙化，伴有相邻巩膜的严重缺血。切除钙化组织和无活力组织后，移植羊膜以覆盖巩膜缺血的广泛区域。
移植后的几周内，观察到羊膜上出现缓慢的上皮化和血管再生，源于周围健康的结膜。
尽管移植部位底部存在缺血一直被视为羊膜移植的禁忌证，但该病例表明，只要周围组织未受影响，移植可能是有效的。在这种情况下，在考虑其他替代方法（如结膜或口腔黏膜自体移植）之前，可以尝试羊膜移植。
