Uemura S, Ienaga K, Higashiura K, Kimura H
Division of Neuroanatomy, Shiga University of Medical Science, Otsu, Japan.
Brain Res. 1992 Oct 30;594(2):347-50. doi: 10.1016/0006-8993(92)91150-d.
Intra-amygdaloid injections of gamma-glutamyltaurine, a recently identified brain dipeptide, strongly suppressed seizures in amygdala-kindled rats stimulated with intensities 10 or 50 microA above the generalized seizure triggering threshold (mean 82 microA). The suppressive effect persisted as long as 3 days. Taurine had relatively weak suppressive effects. Thus gamma-glutamyltaurine seems much more potent than taurine in the suppression of epileptic seizures when injected directly into the kindling site.
向杏仁核内注射γ-谷氨酰牛磺酸（一种最近发现的脑二肽），能强烈抑制杏仁核点燃大鼠的癫痫发作，这些大鼠受到的刺激强度比全身性癫痫发作触发阈值（平均82微安）高10或50微安。这种抑制作用可持续长达3天。牛磺酸的抑制作用相对较弱。因此，当直接注射到点燃部位时，γ-谷氨酰牛磺酸在抑制癫痫发作方面似乎比牛磺酸有效得多。
