Uemura S, Ienaga K, Higashiura K, Kimura H
Miyazaki Mental Saga Hospital, Kyoto, Japan.
Jpn J Psychiatry Neurol. 1991 Jun;45(2):383-5. doi: 10.1111/j.1440-1819.1991.tb02496.x.
Antiepileptic effects of intracerebral injections of taurine and valyltaurine were examined in amygdaloid kindled rats. The effects were assessed whether the animals can evoke generalized seizures by a 10 microA higher stimulation intensity than triggering thresholds. In all fully-kindled animals that have received intraamygdaloid injection of 500 nmol taurine, the kindled seizure was completely abolished. Such a significant seizure suppression (p less than 0.05) was observed 12-24 h after the taurine injection. Valyltaurine (500 nmol) also suppressed the seizure in 60% of animals tested, but the effect was not statistically significant. The results indicate that taurine may effectively suppress epileptic seizures when it acts directly at the stimulation site amygdala.
在杏仁核点燃大鼠中研究了脑内注射牛磺酸和缬氨酰牛磺酸的抗癫痫作用。通过比触发阈值高10微安的刺激强度来评估动物是否能诱发全身性癫痫发作，以此来评价其作用效果。在所有接受杏仁核内注射500纳摩尔牛磺酸的完全点燃动物中，点燃性癫痫发作被完全消除。在注射牛磺酸后12至24小时观察到这种显著的癫痫发作抑制（p小于0.05）。缬氨酰牛磺酸（500纳摩尔）也使60%的受试动物的癫痫发作得到抑制，但该作用无统计学意义。结果表明，当牛磺酸直接作用于刺激部位杏仁核时，可能有效抑制癫痫发作。
